9895/3 Acute myeloid leukemia with myelodysplasia-related changes


Synonyms

Acute myeloid leukemia with multilineage dysplasia
Acute myeloid leukemia with prior myelodysplastic syndrome
Acute myeloid leukemia without prior myelodysplastic syndrome

Definitions

Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C92.8
           

/span>cute myeloid leukaemia (AML) with myelodysplasia-related changes is an acute leukaemia with 20% or more peri?pheral blood (PB) or bone marrow (BM) blasts with morphological features of myelodysplasia or a prior history of a myelodysplastic syndrome (MDS) or myelodysplastic/myeloproliferative neoplasm (MDS/MPN), or MDS-related cytogenetic abnormalities, and absence of the specific genetic abnormalities of AML with recurrent genetic abnormalities. Patients should not have a history of prior cytotoxic or radiation therapy for an unrelated disease. Therefore, there are three possible reasons for assigning cases to this subtype: AML arising from previous MDS or MDS/MPN; AML with an MDS-?related cytogenetic abnormality; and AML with multilineage dysplasia. A given case may be assigned to this subtype for one, two or all three reasons (Table 6.02).

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