8077/2 Squamous intraepithelial neoplasia, high grade
Synonyms
Squamous intraepithelial neoplasia, grade IIICervical intraepithelial neoplasia, grade III
Cin III, NOS
CIN III with severe dysplasia
Vaginal intraepithelial neoplasia, grade III
VAIN III
Vulvar intraepithelial neoplasia, grade III
VIN III
Anal intraepithelial neoplasia, grade III
AIN III
Definitions
Esophagus | ||
ICD-O-3 topography code: | C15 |
Intraepithelial neoplasia is defined as non-invasive cytological or architectural alterations that may lead to the development of invasive carcinoma. The traditional term dysplasia refers to the presence of morphological features of neoplasia 1
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010
The development of oesophageal squamous cell carcinoma (SCC) is a multistep process, progressing from normal squamous epithelium to intraepithelial neoplasia (dysplasia), and eventually to invasive carcinoma 2
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010
High-grade intraepithelial neoplasia (HGIEN) is associated with a high risk of progression to invasive carcinoma. Histological features include cellular disorganization/ loss of polarity and downward growth of the epithelium. Cytological abnormalities include hyperchromasia, increased nucleus:cytoplasm ratio and mitotic activity. In HGIEN, the abnormalities involve the upper half, and cytological alterations are greater than those in low-grade intraepithelial neoplasia (LGIEN).
In the Far East, the terms ?squamous cell carcinoma in situ? and ?noninvasive carcinoma? are used for HGIEN in which the full thickness of the epithelium is involved 3
Click to access Pubmed |
Differences in diagnostic criteria for esophageal squamous cell carcinoma between Japanese and Western pathologists.
Cancer 88: 996-1006
Click to access Pubmed |
The Vienna classification of gastrointestinal epithelial neoplasia.
Gut 47: 251-5
Click to access Pubmed |
Squamous intraepithelial neoplasia of the esophagus: past, present, and future.
J Gastroenterol 44: 103-12
Click to access Pubmed |
Early squamous cell carcinoma of the oesophagus: the Japanese viewpoint.
Histopathology 51: 733-42
Penis | ||
ICD-O-3 topography code: | C60 |
A malignant epithelial neoplasm confined to the squamous epithelium, without invasion of the underlying tissues.
Anus and anal canal | ||
ICD-O-3 topography code: | C21 |
Intraepithelial neoplasia is defined as non-invasive cytological or architectural alterations that may lead to to the development of invasive carcinoma. The traditional term dysplasia refers to the presence of morphological features of neoplasia 7
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010
The development of anal squamous cell carcinoma (SCC) is a multistep process, progressing from normal squamous epithelium to intraepithelial neoplasia (dysplasia), and eventually to invasive carcinoma 8
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010
Anal squamous intraepithelial neoplasia (ASIN) and perianal squamous intraepithelial neoplasia (PSIN) are typically originating from the anal transtional zone and perianal skin respectively. High-grade ASIN and PSIN are associated with a higher risk of progression to invasive carcinoma than low-grade intraepithelial neoplasia. Histological features of intraepitehlial neoplasia include cellular disorganization/ loss of polarity and downward growth of the epithelium. Cytological abnormalities include hyperchromasia, increased nucleus:cytoplasm ratio and mitotic activity.