8077/0 Squamous intraepithelial neoplasia, low grade


Synonyms

Squamous intraepithelial neoplasia, grade I
Squamous intraepithelial neoplasia, grade II


Definitions

Esophagus
ICD-O-3 topography code: C15

Intraepithelial neoplasia is defined as non-invasive cytological or architectural alterations that may lead to to the development of invasive carcinoma. The traditional term dysplasia refers to the the presence of morphological features of neoplasia 1
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.

The development of oesophageal squamous cell carcinoma (SCC) is a multistep process, progressing from normal squamous epithelium to intraepithelial neoplasia (dysplasia), and eventually to invasive carcinoma
2
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



. Low-grade intraepithelial neoplasia (LGIEN) is associated with a low risk of progression to invasive carcinoma. Histological features include cellular disorganization/ loss of polarity and downward growth of the epithelium. Cytological abnormalities include hyperchromasia, increased nucleus:cytoplasm ratio and mitotic activity. In LGIEN these alterations are moderate and involve the lower half of the epithelium.







Anus and anal canal
ICD-O-3 topography code: C21

Intraepithelial neoplasia is defined as non-invasive cytological or architectural alterations that may lead to to the development of invasive carcinoma. The traditional term dysplasia refers to the presence of morphological features of neoplasia
3
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.

The development of anal squamous cell carcinoma (SCC) is a multistep process, progressing from normal squamous epithelium to intraepithelial neoplasia (dysplasia), and eventually to invasive carcinoma
4
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.

Anal squamous intraepithelial neoplasia (ASIN) and perianal squamous intraepithelial neoplasia (PSIN) are typically originating from the anal transtional zone and perianal skin respectively. Low-grade ASIN and PSIN are associated with a low risk of progression to invasive carcinoma. Histological features of intraepitehlial neoplasia include cellular disorganization/ loss of polarity and downward growth of the epithelium. Cytological abnormalities include hyperchromasia, increased nucleus:cytoplasm ratio and mitotic activity.