8588/3 Spindle epithelial tumor with thymus-like element


Synonyms

Spindle epithelial tumor with thymus-like differentiation
SETTLE

Definitions

Thyroid gland
ICD-O-3 topography code: C73
ICD10: C73
           

A rare, slow growing, primary carcinoma of the thyroid gland characterized by a lobulated architectural pattern and the presence of a biphasic cellular population composed of spindle epithelial cells and glandular cells 1
 
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



. A small number of cases are composed exclusively of spindle epithelial cells or glandular cells 2
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Chetty R, Goetsch S, Nayler S, Cooper K (1998)
Spindle epithelial tumour with thymus-like element (SETTLE): the predominantly monophasic variant.
Histopathology 33: 71-4



.

Spindle cell tumour with thymus-like differentiation (SETTLE) usually affects children, adolescents and young adults, with a mean age of 19 years (range 4-59), and a male predominance
3
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Bradford CR, Devaney KO, Lee JI (1999)
Spindle epithelial tumor with thymus-like differentiation: a case report and review of the literature.
Otolaryngol Head Neck Surg 120: 603-6



4
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Hofman P, Mainguené C, Michiels JF, Pages A, Thyss A (1995)
Thyroid spindle epithelial tumor with thymus-like differentiation (the "SETTLE" tumor). An immunohistochemical and electron microscopic study.
Eur Arch Otorhinolaryngol 252: 316-20



5
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Iwasa K, Imai MA, Noguchi M, Tanaka S, Sasaki T, Katsuda S, Kawahara E, Mizukami Y (2002)
Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid.
Head Neck 24: 888-93



. SETTLE is typically associated with delayed blood-borne metastasis. Metastasis usually occurs many years after diagnosis 6
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Chan JK, Rosai J (1991)
Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept.
Hum Pathol 22: 349-67



, although regional metastasis at presentation can sometimes be present. The overall metastatic rate is over 60% with long-term follow-up 7
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Cheuk W, Jacobson AA, Chan JK (2000)
Spindle epithelial tumor with thymus-like differentiation (SETTLE): a distinctive malignant thyroid neoplasm with significant metastatic potential.
Mod Pathol 13: 1150-5



. Metastatic disease, nevertheless, can still be compatible with long survival after treatment 8
 
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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