8512/3 Medullary carcinoma with lymphoid stroma


Definitions

Stomach
ICD-O-3 topography code: C16
ICD10: C16
           

This tumour, also reported as lymphoepithelioma-like carcinoma or medullary carcinoma, is characterized by poorly developed tubular structures associated with a prominent lymphoid infiltration of the stroma. These tumours frequently affect the proximal stomach or gastric stump and are more common in males while > 80% are associated with infection with Epstein-Barr virus (EBV) 1
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Murphy G, Pfeiffer R, Camargo MC, Rabkin CS (2009)
Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location.
Gastroenterology 137: 824-33



. The role of EBV in carcinogenesis is debated, but occurs at an early stage since EBV can be found in adjacent dysplasia. The prognosis for patients with these tumours is reportedly better than that for patients with typical gastric cancers 2
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Matsunou H, Konishi F, Hori H, Ikeda T, Sasaki K, Hirose Y, Yamamichi N (1996)
Characteristics of Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma in Japan.
Cancer 77: 1998-2004



3
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Murphy G, Pfeiffer R, Camargo MC, Rabkin CS (2009)
Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location.
Gastroenterology 137: 824-33



4
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Nakamura S, Ueki T, Yao T, Ueyama T, Tsuneyoshi M (1994)
Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Special reference to its detection by the polymerase chain reaction and in situ hybridization in 99 tumors, including a morphologic analysis.
Cancer 73: 2239-49



5
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Wang HH, Wu MS, Shun CT, Wang HP, Lin CC, Lin JT (1999)
Lymphoepithelioma-like carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection.
Hepatogastroenterology 46: 1214-9



6
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Watanabe H, Enjoji M, Imai T (1976)
Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations.
Cancer 38: 232-43



7
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Willems S, Carneiro F, Geboes K (2005)
Gastric carcinoma with osteoclast-like giant cells and lymphoepithelioma-like carcinoma of the stomach: two of a kind?
Histopathology 47: 331-3



8
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Yamamoto N, Tokunaga M, Uemura Y, Tanaka S, Shirahama H, Nakamura T, Land CE, Sato E (1994)
Epstein-Barr virus and gastric remnant cancer.
Cancer 74: 805-9



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Breast
ICD-O-3 topography code: C50
ICD10: C50
           

An infiltrating breast carcinoma with a relatively favorable prognosis. It is an uncommon carcinoma, accounting for fewer than 1% of all infiltrating breast carcinomas. It is well circumscribed, with soft cut surface and often of considerable size. Microscopically, the predominant growth pattern is syncytial with broad anastomosing bands or sheets of malignant cells. The malignant cells are round with abundant cytoplasm and vesicular nuclei. The sheets of malignant cells are associated with a marked lymphoplasmacytic infiltrate. Glandular or tubular structures are absent.