8041/3 Small cell carcinoma, NOS


Synonyms

Reserve cell carcinoma
Round cell carcinoma


Definitions

Salivary glands
ICD-O-3 topography code: C07-C08
ICD10: C07-C08
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Esophagus
ICD-O-3 topography code: C15
ICD10: C15
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.





Gallbladder and extrahepatic biliary tract
ICD-O-3 topography code: C23-C24.0
ICD10: C23-C24
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.





Hypopharynx, Larynx and Trachea
ICD-O-3 topography code: C13, C32, C33
ICD10: C13, C32, C33
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Stomach
ICD-O-3 topography code: C16
ICD10: C16
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.





Penis
ICD-O-3 topography code: C60
ICD10: C60
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Cervix uteri
ICD-O-3 topography code: C53
ICD10: C53
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.

Cervical small cell carcinoma is rare. Squamous or glandular differentiation may be observed. The tumour is aggressive and has a tendency to rapid recurrence. Mortality is high 1
Click to access Pubmed
Abeler VM, Holm R, Nesland JM, Kjorstad KE (1994)
Small cell carcinoma of the cervix. A clinicopathologic study of 26 patients.
Cancer 73: 672-7



2
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



.



Nasal cavity and Sinuses
ICD-O-3 topography code: C30-C31
ICD10: C30-C31
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Colon and rectum
ICD-O-3 topography code: C18-C20
ICD10: C18-C20
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.





Pancreas
ICD-O-3 topography code: C25
ICD10: C25
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.





Anus and anal canal
ICD-O-3 topography code: C21
ICD10: C21
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Bronchus and lung
ICD-O-3 topography code: C34
ICD10: C34
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Thymus
ICD-O-3 topography code: C37
ICD10: C37
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Small intestine
ICD-O-3 topography code: C17
ICD10: C17
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.





Region of the ampulla of Vater
ICD-O-3 topography code: C24.1
ICD10: C24.1
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.





Corpus uteri
ICD-O-3 topography code: C54
ICD10: C54
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.

Small cell carcinoma of the uterine corpus is an uncommon endometrial carcinoma. The prognosis is far better than for small cell carcinomas elsewhere in the female genital tract; 5-year survival for stage I disease is about 60%
3
Click to access Pubmed
Abeler VM, Kjorstad KE, Nesland JM (1991)
Undifferentiated carcinoma of the endometrium. A histopathologic and clinical study of 31 cases.
Cancer 68: 98-105



4
Click to access Pubmed
Huntsman DG, Clement PB, Gilks CB, Scully RE (1994)
Small-cell carcinoma of the endometrium. A clinicopathological study of sixteen cases.
Am J Surg Pathol 18: 364-75



5
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



.



Urinary system: Renal pelvis, ureter, bladder, urethra
ICD-O-3 topography code: C65-C68
ICD10: C65-C68
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Ovary
ICD-O-3 topography code: C56
ICD10: C56
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Prostate gland
ICD-O-3 topography code: C61
ICD10: C61
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.



Vulva
ICD-O-3 topography code: C51
ICD10: C51
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.

Small cell carcinoma of the vulva is a rare tumour that can arise at the site of the Bartholin gland
6
Click to access Pubmed
Jones MA, Mann EW, Caldwell CL, Tarraza HM, Dickersin GR, Young RH (1990)
Small cell neuroendocrine carcinoma of Bartholin's gland.
Am J Clin Pathol 94: 439-42



, resulting in an enlargement of the Bartholin gland area that may resemble a Bartholin duct cyst. Patients are predominantly older women >50 years of age. Approximately 20% of patients have ipsilateral inguinofemoral lymph node metastases at presentation7
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



.



Breast
ICD-O-3 topography code: C50
ICD10: C50
           

This carcinoma is morphologically indistinguishable from its counterpart in the lung on the basis of histological and immunohistochemical features
8
Click to access Pubmed
Shin SJ, DeLellis RA, Ying L, Rosen PP (2000)
Small cell carcinoma of the breast: a clinicopathologic and immunohistochemical study of nine patients.
Am J Surg Pathol 24: 1231-8



. The tumours are composed of densely packed hyperchromatic cells with scant cytoplasm and display an infiltrative growth pattern. Large numbers of mitotic figures and focal areas of necrosis are present 9
Click to access Pubmed
Sapino A, Righi L, Cassoni P, Papotti M, Gugliotta P, Bussolati G (2001)
Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women.
Mod Pathol 14: 768-76



. An in situ component with the same cytological features may be detected. Lymphatic tumour emboli are frequently encountered.

See Carcinoma with neuroendocrine features for images and detailed discussion.





Vagina
ICD-O-3 topography code: C52
ICD10: C52
           

A neuroendocrine carcinoma composed of small malignant cells which histologically often resemble "oat cells". Clinically, this is often a rapidly growing cancer that spreads to distant sites early.