8430/3 Mucoepidermoid carcinoma


Definitions

Lip, Oral Cavity and Oropharynx
ICD-O-3 topography code: C00-C06, C09-C10, C14
ICD10: C00-C06, C09-C10, C14
           

A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It is classified as low or high grade.



Salivary glands
ICD-O-3 topography code: C07-C08
ICD10: C07-C08
           

A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It is classified as low or high grade.



Thyroid gland
ICD-O-3 topography code: C73
ICD10: C73
           

A carcinoma morphologically characterized by the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It is classified as low or high grade.

Mucoepidermoid carcinoma (MEC) of the thyroid comprises about 0.5% of all thyroid malignancies 1
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Franssila KO, Harach HR, Wasenius VM (1984)
Mucoepidermoid carcinoma of the thyroid.
Histopathology 8: 847-60



and shares most of the epidemiological features of papillary carcinoma 2
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Rocha AS, Soares P, Machado JC, Máximo V, Fonseca E, Franssila K, Sobrinho-Simões M (2002)
Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex.
Virchows Arch 440: 498-504



. This tumour affects women more frequently than men (2:1), and has a bimodal age distribution.
Thyroid MECs are low grade malignant tumours with an indolent biological behaviour and excellent long term prognosis
3
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Cameselle-Teijeiro J, Febles-Pérez C, Sobrinho-Simões M (1995)
Papillary and mucoepidermoid carcinoma of the thyroid with anaplastic transformation: a case report with histologic and immunohistochemical findings that support a provocative histogenetic hypothesis.
Pathol Res Pract 191: 1214-21



4
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Vázquez Ramírez F, Otal Salaverri C, Argueta Manzano O, Galera Ruíz H, González-Cámpora R (2000)
Fine needle aspiration cytology of high grade mucoepidermoid carcinoma of the thyroid. A case report.
Acta Cytol 44: 259-64



. Extrathyroidal invasion and regional nodal metastases may occur but distant metastases are rare 5
 
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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Hypopharynx, Larynx and Trachea
ICD-O-3 topography code: C13, C32, C33
ICD10: C13, C32, C33
           

A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It is classified as low or high grade.



Esophagus
ICD-O-3 topography code: C15
ICD10: C15
           

Mucoepidermoid carcinoma is morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It is classified as low or high grade.

In the esophagus, this tumour is rare, with a typical mixture of squamous cells, mucus-secreting cells and cells of an intermediate type
6
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Tamura S, Kobayashi K, Seki Y, Matsuyama J, Kagara N, Ukei T, Uemura Y, Miyauchi K, Kaneko T (2003)
Mucoepidermoid carcinoma of the esophagus treated by endoscopic mucosal resection.
Dis Esophagus 16: 265-7



7
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Nasal cavity and Sinuses
ICD-O-3 topography code: C30-C31
ICD10: C30-C31
           

A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It is classified as low or high grade.



Bronchus and lung
ICD-O-3 topography code: C34
ICD10: C34
           

A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It is classified as low or high grade.



Thymus
ICD-O-3 topography code: C37
ICD10: C37
           

A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It is classified as low or high grade.



Breast
ICD-O-3 topography code: C50
ICD10: C50
           

A primary breast carcinoma that is histologically similar to its counterpart in the salivary gland, and that concomitantly shows basaloid, intermediate, epidermoid and mucinous cells.