8408/3 Eccrine papillary adenocarcinoma



Definitions

Skin
ICD-O-3 topography code: C44
ICD10: C44
           

Eccrine (digital) papillary adenocarcinoma is an uncommon malignant adnexal neoplasm, supposedly of eccrine origin, and arising almost exclusively on fingers, toes, palms, and soles. The tumours are well-circumscribed or infiltrative and may reach several cm in diameter. Most cases present as deeply seated nodular lesions in the dermis that may extend into the underlying bone, joint, or nerve. The nodules consist of epithelial cells. There are frequent cystic spaces that contain papillary epithelial projections and either necrotic debris or eosinophilic secretory material. The solid areas of the tumour are often filled with glands arranged in a cribriform pattern. Necrosis is common.
Digital papillary carcinoma mainly affects adults in the 5th and 6th decades of life and shows a predilection for males. Recommended treatment is complete surgical excision with negative margins; sometimes amputation of the affected digit is indicated. The tumours recur in up to 50% of patients; metastases develop in approximately 15% of cases, preferentially in the lungs1
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



.