8013/3 Large cell neuroendocrine carcinoma


Definitions

Gallbladder and extrahepatic biliary tract
ICD-O-3 topography code: C23-C24.0
ICD10: C23-C24
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.





Esophagus
ICD-O-3 topography code: C15
ICD10: C15
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.





Stomach
ICD-O-3 topography code: C16
ICD10: C16
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.





Colon and rectum
ICD-O-3 topography code: C18-C20
ICD10: C18-C20
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.





Pancreas
ICD-O-3 topography code: C25
ICD10: C25
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.





Ovary
ICD-O-3 topography code: C56
ICD10: C56
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.



Thymus
ICD-O-3 topography code: C37
ICD10: C37
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.



Small intestine
ICD-O-3 topography code: C17
ICD10: C17
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.





Region of the ampulla of Vater
ICD-O-3 topography code: C24.1
ICD10: C24.1
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.





Anus and anal canal
ICD-O-3 topography code: C21
ICD10: C21
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.



Bronchus and lung
ICD-O-3 topography code: C34
ICD10: C34
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.



Cervix uteri
ICD-O-3 topography code: C53
ICD10: C53
           

A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas1
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Breast
ICD-O-3 topography code: C50
ICD10: C50
           

Large cell neuroendocrine carcinoma of the breast is a poorly differentiated, usually aggressive tumour composed of large clusters of malignant cells which display neuroendocrine characteristics. Mitotic activity is high. Foci of necrosis are present.
Only about 15% of neuroendocrine breast carcinomas are poorly differentiated. One of the most important prognostic parameters is histological grading
2
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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