9983/3 Refractory anemia with excess blasts




Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: D46.2

/span>efractory anaemia with excess blasts (RAEB) is a myelodysplastic syndrome (MDS) with 5−19% myeloblasts in the bone marrow (BM) or 2−19% blasts in the peripheral blood (PB). Because of differences in survival and incidence of evolution to acute myeloid leukaemia (AML), two categories of RAEB are recognized: RAEB-1, defined by 5−9% blasts in the BM or 2−4% blasts in the PB, and RAEB-2, defined by 10−19% blasts in the BM or 5−19% blasts in the PB 1
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Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J (1997)
International scoring system for evaluating prognosis in myelodysplastic syndromes.
Blood 89: 2079-88

. The presence of Auer rods in blasts qualifies a case as RAEB-2 irrespective of the blast percentage 2
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Germing U, Strupp C, Kuendgen A, Aivado M, Giagounidis A, Hildebrandt B, Aul C, Haas R, Gattermann N (2006)
Refractory anaemia with excess of blasts (RAEB): analysis of reclassification according to the WHO proposals.
Br J Haematol 132: 162-7