9690/3 Malignant lymphoma, centroblasticcentrocytic, follicular


Related terms

Follicular lymphoma, NOS

Definitions

Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C82.9
           

/span>ollicular lymphoma (FL) is a neoplasm composed of follicle centre (germinal centre) B-cells (typically both centrocytes and centroblasts/large transformed cells), which usually has at least a partially follicular pattern. If diffuse areas of any size comprised predominantly or entirely of blastic cells are present in any case of follicular lymphoma, a diagnosis of diffuse large B-cell lymphoma is also made. Lymphomas composed of centrocytes and centroblasts with an entirely diffuse pattern in the sampled tissue may be included in this category. Primary cutaneous follicle centre lymphomas are separately classified 1
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



2
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



.

> >Bacon CM, Ye H, Diss TC, McNamara C, Kueck B, Hasserjian RP, Rohatiner AZ, Ferry J, Du MQ, Dogan A (2007)
Primary follicular lymphoma of the testis and epididymis in adults.
Am J Surg Pathol 31: 1050-8



.

Related Topics>



Lip, Oral Cavity and Oropharynx
ICD-O-3 topography code: C00-C06, C09-C10, C14
ICD10: C82.9
           

Follicular lymphoma (FL) is a neoplasm composed of follicle centre (germinal centre) B-cells (typically both centrocytes and centroblasts/large transformed cells), which usually has at least a partially
follicular pattern.
FL accounts for about 20% of all lymphomas, with the highest incidence in the USA and Western Europe. It affects predominantly adults, with a median age in the 6th decade and a male:female ratio of 1:1.7. FL rarely occurs in individuals under the age of 20 years.

Primary cutaneous follicle centre lymphomas are separately classified
5
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



6
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



.



Breast
ICD-O-3 topography code: C50
ICD10: C82.9
           

Follicular lymphoma (FL) is a neoplasm composed of follicle centre (germinal centre) B-cells (typically both centrocytes and centroblasts/large transformed cells), which usually has at least a partially follicular pattern.





Small intestine
ICD-O-3 topography code: C17
ICD10: C17
           

Follicular lymphoma (FL) is a neoplasm composed of follicle centre (germinal centre) B-cells (typically both centrocytes and centroblasts/large transformed cells), which usually has at least a partially follicular pattern. FL accounts for about 20% of all lymphomas, with the highest incidence in the USA and Western Europe. It affects predominantly adults, with a median age in the 6th decade and a male:female ratio of 1:1.7. FL rarely occurs in individuals under the age of 20 years.

Intestinal FL occurs mainly in the duodenum
9
Click to access Pubmed
Sato Y, Ichimura K, Tanaka T, Takata K, Morito T, Sato H, Kondo E, Yanai H, Ohara N, Oka T, Yoshino T (2008)
Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas.
J Clin Pathol 61: 377-81



10
Click to access Pubmed
Schildhaus HU, Cavlar T, Binot E, BŁttner R, Wardelmann E, Merkelbach-Bruse S (2008)
Inflammatory fibroid polyps harbour mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene.
J Pathol 216: 176-82



and often presents as multiple small polyps. Most are localized to the intestine (primary intestinal FL) and some are an extension from primary nodal FLs. The immunophenotype and genetic features of primary intestinal FL are similar to those of nodal FLs. The localized form is associated with an excellent survival, even without treatment11
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



.

Primary cutaneous follicle centre lymphomas are separately classified
12
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



13
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



.



Skin
ICD-O-3 topography code: C44
ICD10: C82.9
           

Follicular lymphoma (FL) is a neoplasm composed of follicle centre (germinal centre) B-cells (typically both centrocytes and centroblasts/large transformed cells), which usually has at least a partially
follicular pattern.
FL accounts for about 20% of all lymphomas, with the highest incidence in the USA and Western Europe. It affects predominantly adults, with a median age in the 6th decade and a male:female ratio of 1:1.7. FL rarely occurs in individuals under the age of 20 years.

Primary cutaneous follicle centre lymphomas are separately classified
14
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



15
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



.