9689/3 Splenic marginal zone B-cell lymphoma


Splenic marginal zone lymphoma, NOS
Splenic lymphoma with villous lymphocytes


Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C83.0

/span>plenic marginal zone lymphoma (SMZL) is a B-cell neoplasm composed of small lymphocytes which surround and replace the splenic white pulp germinal centres, efface the follicle mantle and merge with a peripheral (marginal) zone of larger cells including scattered transformed blasts; both small and larger cells infiltrate the red pulp. Splenic hilar lymph nodes and bone marrow (BM) are often involved; lymphoma cells may be found in the peripheral blood (PB) as villous lymphocytes.