9451/3 Oligodendroglioma, anaplastic


Tumours of the central nervous system
ICD-O-3 topography code: C70, C71 and C72
ICD10: C71

An oligodendroglioma with focal or diffuse malignant morphologic features (WHO grade III) and less favourable prognosis 1
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (Eds.)
WHO Classification of Tumours of the Central Nervous System.
4th Edition
International Agency for Research on Cancer: Lyon 2007

. LOH 1p/19 is a genetic hallmark and confers an increased response ro radio-/chemotherapy with significant increase in survival 2
Click to access Pubmed
Intergroup Radiation Therapy Oncology Group Trial 9402, Cairncross G, Berkey B, Shaw E, Jenkins R, Scheithauer B, Brachman D, Buckner J, Fink K, Souhami L, Laperierre N, Mehta M, Curran W (2006)
Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402.
J Clin Oncol 24: 2707-14

. On a population-based level, 5 and 10 years survival rates of 47% and 34% have been reported http://www.cbtrus.org/reports/reports.html .