9400/3 Astrocytic glioma



Definitions

Tumours of the central nervous system
ICD-O-3 topography code: C70, C71 and C72
ICD10: C71
           

An astrocytic neoplasm characterised by a high degree of cellular differentiation, slow growth, and diffuse infiltration of neighbouring brain structures (WHO grade II) 1
 
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (Eds.)
WHO Classification of Tumours of the Central Nervous System.
4th Edition
International Agency for Research on Cancer: Lyon 2007



. These lesions occur at any site in the CNS, but preferentially in the cerebal hemispheres. They typically affect young adults and have an intrinsic tendency for malignant progression to anaplastic astrocytoma and, ultimately, secondary glioblastoma. Progression to glioblastoma occurs after a mean interval of approximately 5 years. Genetic hallmarks include TP53 and IDH1 mutations.

Histological subtypes of diffuse astrocytoma:
Fibrillary astrocytoma
Protoplasmic astrocytoma
Gemistocytic astrocytoma