8260/3 Papillary adenocarcinoma, NOS



Definitions

Stomach
ICD-O-3 topography code: C16
ICD10: C16
           

Papillary adenocarcinoma is a malignant epithelial neoplasm composed of glandular cells and characterized by a papillary growth pattern.

Papillary adenocarcinoma of the stomach is a well-differentiated exophytic carcinoma with elongated finger-like processes lined by cylindrical or cuboidal cells supported by fibrovascular connective tissue cores. The cells tend to maintain their polarity. Some tumours show tubular (papillotubular) differentiation. Rarely, micropapillary architecture is present. The degree of cellular atypia and mitotic index vary; there may be severe nuclear atypia. The invading edge of the tumour is usually sharply demarcated; the tumour may be infiltrated by acute and chronic inflammatory cells.



Kidney
ICD-O-3 topography code: C64
ICD10: C64
           

/span>apillary adenocarcinoma is a malignant epithelial neoplasm composed of glandular cells and characterized by a papillary growth pattern.

Papillary renal cell carcinomas account for approximately 10% of malignant renal parenchymal tumours in adults. The following morphological types of pRCC are distinguished 1
 
Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



2
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Srigley JR, Delahunt B (2009)
Uncommon and recently described renal carcinomas.
Mod Pathol 22 Suppl 2: S2-S23



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Tickoo SK, dePeralta-Venturina MN, Harik LR, Worcester HD, Salama ME, Young AN, Moch H, Amin MB (2006)
Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia.
Am J Surg Pathol 30: 141-53



, but alo in otherwise unaffected kidneys. It is histologicall caracterized by papillary structures lined by cells with clear cytoplasm which typically occur within cysts that are also lined by clear epithelial cells 5
Click to access Pubmed
Srigley JR, Delahunt B (2009)
Uncommon and recently described renal carcinomas.
Mod Pathol 22 Suppl 2: S2-S23



.

Oncocytic papillary renal cell carcinoma>



Region of the ampulla of Vater
ICD-O-3 topography code: C24.1
ICD10: C24.1
           

Exophytic neoplasms with a papillary architecture can occur in the ampulla, similar to those arising in the gallbladder and extrahepatic bile ducts. In the past, these neoplasms have been classified as noninvasive and invasive papillary carcinomas
8
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Albores-Saavedra J, Murakata L, Krueger JE, Henson DE (2000)
Noninvasive and minimally invasive papillary carcinomas of the extrahepatic bile ducts.
Cancer 89: 508-15



9
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Albores-Saavedra J, Tuck M, McLaren BK, Carrick KS, Henson DE (2005)
Papillary carcinomas of the gallbladder: analysis of noninvasive and invasive types.
Arch Pathol Lab Med 129: 905-9



10
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Hoang MP, Murakata LA, Katabi N, Henson DE, Albores-Saavedra J (2002)
Invasive papillary carcinomas of the extrahepatic bile ducts: a clinicopathologic and immunohistochemical study of 13 cases.
Mod Pathol 15: 1251-8



. Noninvasive lesions are now designated ?noninvasive papillary neoplasms.? When an invasive carcinoma arises in association with a noninvasive papillary neoplasm, the invasive component should be diagnosed, graded, and staged separately from the noninvasive component.

Papillary adenocarcinoma of the ampulla of Vater
In the ampulla, most such invasive carcinomas are of pancreatobiliary or intestinal type. Only rarely does an invasive carcinoma maintain a papillary growth pattern in the invasive elements, and although a descriptive term of ?invasive papillary carcinoma? could be used for these neoplasms, most can be more accurately classified on the basis of cellular differentiation and morphology as one of the other histological variants of ampullary carcinoma
11
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Thyroid gland
ICD-O-3 topography code: C73
ICD10: C73
           

Papillary adenocarcinoma of the thyroid is a malignant epithelial tumour histologically characterized by follicular cell differentiation, distinctive nuclear features and a papillary growth pattern. Papillary carcinomas are reactive for
cytokeratins, thyroglobulin and thyroid
transcription factor?1 (TTF-1)Most tumours manifest in adults of 20-50 years, with a female to male ratio of 4:1. The overall survival is greater than 90%, particularly for patients younger than 45 years. Although this neoplasm is rare before the age of 15 years, it represents the most common paediatric thyroid malignancy. The etiology of papillary thyroid carcinoma is closely linked to radiation exposure
12
 
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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Prostate gland
ICD-O-3 topography code: C61
ICD10: C61.9
           

Papillary adenocarcinoma is a malignant epithelial neoplasm composed of glandular cells and characterized by a papillary growth pattern.



Bronchus and lung
ICD-O-3 topography code: C34
ICD10: C34
           

Papillary adenocarcinoma is a malignant epithelial neoplasm composed of glandular cells and characterized by a papillary growth pattern.



Nasopharynx
ICD-O-3 topography code: C11
ICD10: C11.9
           

Papillary adenocarcinoma is a malignant epithelial neoplasm composed of glandular cells and characterized by a papillary growth pattern.



Gallbladder and extrahepatic biliary tract
ICD-O-3 topography code: C23-C24.0
ICD10: C23-C24
           

Papillary adenocarcinoma is a malignant epithelial neoplasm composed of glandular cells and characterized by a papillary growth pattern.



Thymus
ICD-O-3 topography code: C37
ICD10: C37
           

Papillary adenocarcinoma is a malignant epithelial neoplasm composed of glandular cells and characterized by a papillary growth pattern.