9252/0 Giant cell tumor of tendon sheath



Definitions

Connective, subcutaneous and other soft tissues
ICD-O-3 topography code: C49

Giant cell tumour of tendon sheath is a lesion usually arising in the synovium of joints, bursa or tendon sheath. It is histologically characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse (for the latter, see diffuse-type giant cell tumor).
Localized giant cell tumours of tendon sheath arise predominantly in the hands, particularly in the fingers. Other common sites are wrist, ankle/foot and knee. Most lesions are small (0.5 - 4 cm), well circumscribed, lobulated, and at least partially surrounded by a fibrous capsule. Occasionally, they infiltrate or erode the adjacent bone or joint.
The localized form of giant cell tumour of tendon sheath is a benign lesion and the most common subtype of giant cell tumours. It occurs in all age groups, with a peak incidence between 30 and 50 years. Females are more often affected (ratio 2:1). Treatment of choice is local excision. Recurrence is observed in up to 30% of cases, but it is generally non-destructive 1
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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