9100/3 Chorioepithelioma


Related terms

Choriocarcinoma, NOS

Definitions

Tumours of the central nervous system
ICD-O-3 topography code: C70, C71 and C72
ICD10: C71
           

An aggressive malignant tumour arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Histopathologically, choriocarcinomas consist of an admixture of syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast, typically with haemorrhage, necrosis and vascular invasion 1
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



. There is often a marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas tend to disseminate through the hematogenous route.



Fallopian tube and Uterine ligaments
ICD-O-3 topography code: C57
ICD10: C57
           

An aggressive malignant tumour arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Histopathologically, choriocarcinomas consist of an admixture of syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast, typically with haemorrhage, necrosis and vascular invasion
2
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



. There is often a marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas tend to disseminate through the hematogenous route.



Thymus
ICD-O-3 topography code: C37
ICD10: C37
           

An aggressive malignant tumour arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Histopathologically, choriocarcinomas consist of an admixture of syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast, typically with haemorrhage, necrosis and vascular invasion
3
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



. There is often a marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas tend to disseminate through the hematogenous route.



Ovary
ICD-O-3 topography code: C56
ICD10: C56
           

An aggressive malignant tumour arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Histopathologically, choriocarcinomas consist of an admixture of syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast, typically with haemorrhage, necrosis and vascular invasion
4
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



. There is often a marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas tend to disseminate through the hematogenous route.



Corpus uteri
ICD-O-3 topography code: C54
ICD10: C54
           

Choriocarcinoma is an aggressive malignant tumour composed of large sheets of highly atypical trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Gestational choriocarcinoma may occur subsequent to a molar pregnancy (50% of cases), an abortion (25%), a normal gestation (22.5%) or an ectopic pregnancy (2.5%). Histopathologically, choriocarcinomas consist of an admixture of syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast, typically with haemorrhage, necrosis and vascular invasion. The tumour lacks stroma and vessels; the viable tumour is correspondingly located at the periphery of haemorrhagic foci. There is often a marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas tend to disseminate through the hematogenous route
5
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



.



Prostate gland
ICD-O-3 topography code: C61
ICD10: C61
           

An aggressive malignant tumour arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Histopathologically, choriocarcinomas consist of an admixture of syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast, typically with haemorrhage, necrosis and vascular invasion
6
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



. There is often a marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas tend to disseminate through the hematogenous route.



Testis/Male genital organs
ICD-O-3 topography code: C62-C63
ICD10: C62-C63
           

An aggressive malignant tumour arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Histopathologically, choriocarcinomas consist of an admixture of syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast, typically with haemorrhage, necrosis and vascular invasion
7
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



. There is often a marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas tend to disseminate through the hematogenous route.



Kidney
ICD-O-3 topography code: C64
ICD10: C64
           

Choriocarcinoma is an aggressive malignant tumour arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Histopathologically, choriocarcinomas consist of an admixture of syncytiotrophoblasts, cytotrophoblasts, and intermediate trophoblasts, typically with haemorrhage, necrosis and vascular invasion
8
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



. There is often a marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas tend to disseminate through the haematogenous route.

Primary renal choriocarcinomas are rare and difficult to distinguish from high grade urothelial carcinomas with syncytiotrophoblasts. Most cases are metastases from testicular germ cell tumours
9
 
Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



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