8930/0 Endometrial stromal nodule


Corpus uteri
ICD-O-3 topography code: C54

Endometrial stromal nodule is a non-infiltrating, benign mesenchymal neoplasm arising from the uterine corpus. The tumour is typically a solitary, well delineated, round to oval nodule with an expansive margin and ranging in diameter from 0.8 to 15 cm (median 4 cm). Approximately two-thirds of cases are purely intramural. Histologically, the lesion is characterized by neoplastic cells that resemble the cells of the proliferating endometrial stroma and numerous thin-walled small vessels. Foci of smooth and skeletal muscle along with sex cord differentiation may be present.
Patients range in age from 23-75 years (median 47 years); about one-third of cases arise in postmenopausal women. Clinically, the tumour usually presents with abnormal uterine bleeding and menorrhagia. Endometrial stromal nodules are benign lesions. Incomplete excision may necessitate a hysterectomy1
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003