8574/3 Adenocarcinoma with neuroendocrine differentiation


Carcinoma with neuroendocrine differentiation


Prostate gland
ICD-O-3 topography code: C61
ICD10: C61

An invasive adenocarcinoma characterized by the presence of focal or extensive neurosecretory cell differentiation with the formation of organoid patterns.

ICD-O-3 topography code: C50
ICD10: C50

Neuroendocrine differentiation as determined by histochemical and immunohistochemical analysis occurs more frequently (up to 30%) in invasive carcinoma NST and other special types, particularly mucinous carcinomas. Mucinous carcinomas, hypercellular variant, represent approximately one quarter of mammary carcinomas with neuroendocrine differentiation 1
Click to access Pubmed
Sapino A, Righi L, Cassoni P, Papotti M, Gugliotta P, Bussolati G (2001)
Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women.
Mod Pathol 14: 768-76

, are almost invariably of low grade 2
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Nishizaki T, Chew K, Chu L, Isola J, Kallioniemi A, Weidner N, Waldman FM (1997)
Genetic alterations in lobular breast cancer by comparative genomic hybridization.
Int J Cancer 74: 513-7

. Solid papillary carcinomas frequently show neuroendocrine differentiation in both in situ and invasive components.

See Carcinoma with neuroendocrine features for images and detailed discussion.