8570/3 Adenocarcinoma with squamous metaplasia




Corpus uteri
ICD-O-3 topography code: C54
ICD10: C54

Adenocarcinoma with squamous differentiation is the most common variant of endometrioid adenocarcinoma, characterized by varying amounts of neoplastic squamous epithelial cells. The squamous or morular elements are not considered a part of the solid component and therefore do not increase the grade of an endometrioid carcinoma. The criteria for squamous differentiation are1
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003

- keratinization
- intercellular bridges and/or
- three or more of the following four criteria:
a) sheet-like growth without gland formation or palisading
b) sharp cell margins
c) eosinophilic and thick or glassy cytoplasm
d) a decreased nuclear to cytoplasmic ratio as compared with foci elsewhere in the same tumour