8211/0 Tubular adenoma, NOS


Definitions

Colon and rectum
ICD-O-3 topography code: C18-C20

An adenoma whose cells are arranged in tubules. Tubules may vary in size and often occur singly.
Most colorectal adenomas have tubular architecture1
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Small intestine
ICD-O-3 topography code: C17

An adenoma whose cells are arranged in tubules. Tubules may vary in size and often occur singly.



Gallbladder and extrahepatic biliary tract
ICD-O-3 topography code: C23-C24.0

Tubular adenoma, pyloric-gland type (pyloric- gland adenoma) is the most common variant of gallbladder adenoma. It is composed of lobules of closely packed pyloric-type glands, some of which may be cystically dilated, often covered by normal biliary epithelium. Squamoid morules characterized by nodular aggregates of cytologically bland spindle cells with eosinophilic cytoplasm but no keratinization are also seen
2
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Kushima R, Remmele W, Stolte M, Borchard F (1996)
Pyloric gland type adenoma of the gallbladder with squamoid spindle cell metaplasia.
Pathol Res Pract 192: 963-9; discussion 970-1



3
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Nishihara K, Yamaguchi K, Hashimoto H, Enjoji M (1991)
Tubular adenoma of the gallbladder with squamoid spindle cell metaplasia. Report of three cases with immunohistochemical study.
Acta Pathol Jpn 41: 41-5



. Paneth cells and neuroendocrine cells are often present. By definition, pyloric-gland adenomas have at least low-grade intraepithelial neoplasia. Larger adenomas may have high-grade intraepithelial neoplasia or may be associated with foci of invasive carcinoma. As they enlarge, some develop a pedicle and project into the lumen. Rarely, they extend into or arise from Rokitansky-Aschoff sinuses, a finding that should not be mistaken for invasive carcinoma 4
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Albores-Saavedra J, Vardaman CJ, Vuitch F (1993)
Non-neoplastic polypoid lesions and adenomas of the gallbladder.
Pathol Annu 28 Pt 1: 145-77



5
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Skin
ICD-O-3 topography code: C44

Tubular adenoma is a slow-growing, benign adnexal neoplasm with apocrine differentiation. It typically arises on the scalp; less commonly affected sites include legs, trunk, axillary and anogenital areas. Tubular adenomas present as asymptomatic, skin-coloured to pink-red, well-circumscribed solitary nodules measuring 1-2cm (rare cases up to 7cm). The tumour develops in the dermis and may extend into subcutaneous tissue. The tumour architecture is lobular; the lobules consist of tubular structures with a two- or multi-layered epithelial lining and are typically encased by a fibrous stroma. The overlying epidermis may be hyperplastic.
Tubular adenomas affect a broad age group and show a predilection for women. Tubular apocrine adenomas are cured by simple excision
6
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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Breast
ICD-O-3 topography code: C50

Benign, usually round, nodules formed by a compact proliferation of tubular structures lined by epithelial and myoepithelial cells, similar to those of the normal resting breast.






Region of the ampulla of Vater
ICD-O-3 topography code: C24.1

An adenoma whose cells are arranged in tubules. Tubules may vary in size and often occur singly.

Tubular adenomas of the region of the ampulla of Vater are usually smaller than villous or tubulovillous adenomas and have a polypoid growth pattern
8
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Perzin KH, Bridge MF (1981)
Adenomas of the small intestine: a clinicopathologic review of 51 cases and a study of their relationship to carcinoma.
Cancer 48: 799-819



. They consist of tubular glands resembling the basal portions of the intestinal crypts 9
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Vagina
ICD-O-3 topography code: C52