8441/3 Serous adenocarcinoma, NOS



Definitions

Pancreas
ICD-O-3 topography code: C25
ICD10: C25
           

A malignant neoplasm composed of uniform glycogen-rich cuboidal invasive epithelial cells that usually form papillary projections and cysts containing serous fluid. Malignancy is defined by the presence of distant metastases1
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Some 1?3% of serous cystic neoplasms of the pancreas are malignant, but they are rare. They are slowly growing neoplasms and palliative resection may be helpful even at an advanced stage. With a mean follow-up of 36 months, most patients were still alive at the time their cases were reported
2
Click to access Pubmed
King JC, Ng TT, White SC, Cortina G, Reber HA, Hines OJ (2009)
Pancreatic serous cystadenocarcinoma: a case report and review of the literature.
J Gastrointest Surg 13: 1864-8



3
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Ovary
ICD-O-3 topography code: C56
ICD10: C56
           

A malignant serous cystic neoplasm characterized by the presence of invasive malignant glandular epithelial cells which often form papillary structures.



Corpus uteri
ICD-O-3 topography code: C54
ICD10: C54
           

Serous adenocarcinoma is a high-grade primary adenocarcinoma arising from the endometrium. Histologically, it is characterized by invasive malignant glandular epithelium which often forms complex papillary structures with broad fibrovascular cores, cellular budding and sloughing of the cells. The cells are usually rounded. Multinucleated cells, mitoses, solid cell nests and foci of necrosis are common features. Approximately 30% of cases contain psammoma bodies. Serous adenocarcinomas belong to the group of non-estrogen-dependent tumours. A putative precursor lesion is serous endometrial intraepithelial carcinoma.
Serous adenocarcinomas are aggressive tumours with a tendency to deep myometrial and extensive lymphatic invasion. Extrauterine spread and recurrence are common and frequently result in death of the patient
4
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Fallopian tube and Uterine ligaments
ICD-O-3 topography code: C57
ICD10: C57
           

A malignant serous cystic neoplasm characterized by the presence of invasive malignant glandular epithelial cells which often form papillary structures.



Cervix uteri
ICD-O-3 topography code: C53
ICD10: C53
           

Serous cystadenocarcinoma is a malignant neoplasm characterized by the presence of invasive malignant glandular epithelial cells which often form complex papillary structures. Psammoma bodies are frequently present.

Primary cervical serous cystadenocarcinomas are rare
5
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Testis/Male genital organs
ICD-O-3 topography code: C62-C63
ICD10: C62-C63
           

A malignant serous cystic neoplasm characterized by the presence of invasive malignant glandular epithelial cells which often form papillary structures.