8380/3 Endometrioid carcinoma, NOS



Definitions

Corpus uteri
ICD-O-3 topography code: C54
ICD10: C54
           

Endometrioid adenocarcinoma of the uterine corpus is a primary endometrial adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. The great majority of patients present with abnormal uterine bleeding. The uterus is frequently enlarged. The tumour generally appears as a single dominant mass. It may extend into the underlying myometrium; advanced cases may penetrate the serosa or extend into the cervix. Highly characteristic histological features of endometrioid adenocarcinoma are glandular/villoglandular structures lined by columnar cells. In higher grade tumours, the fraction of glandular cells decreases and is replaced by solid nests and sheets of cells.
In addition to glandular cells, a variety of other differentiated epithelial cell types may be found in endometrial proliferations, including squamous/morular, mucinous, ciliated, cleared or eosinophilic cells; when these cell types are prominent in a tumour, it is termed a "special variant" carcinoma and subclassified into:

- variant with squamous differentiation
- villloglandular variant
- secretory variant
- ciliated cell variant

Endometrioid adenocarcinoma is the most common type of endometrial carcinomas. Most cases arise in postmenopausal women. The tumour is estrogen-dependent; driving force is unopposed estrogenic stimulation. Patients are frequently obese, diabetic, nulliparous, hypertensive, or have a late menopause. Most tumours are low-grade and have a favourable prognosis1
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Cervix uteri
ICD-O-3 topography code: C53
ICD10: C53
           

Endometrioid adenocarcinoma is an adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament.

Endometrioid adenocarcinomas account for up to 30% of cervical adenocarcinomas. Compared with endometrioid adenocarcinomas of the endometrium, squamous elements are less common. There is little or no intracellular mucin
2
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Ovary
ICD-O-3 topography code: C56
ICD10: C56
           

An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament.



Vagina
ICD-O-3 topography code: C52
ICD10: C52
           

An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament.



Fallopian tube and Uterine ligaments
ICD-O-3 topography code: C57
ICD10: C57
           

An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament.



Testis/Male genital organs
ICD-O-3 topography code: C62-C63
ICD10: C62-C63
           

An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament.