8370/0 Adrenal cortical tumor, benign



Definitions

Adrenal gland
ICD-O-3 topography code: C74

Adrenal cortical adenoma is a benign epithelial neoplasm of the adrenal cortical layers. It can be associated with the overproduction of glucocorticoids (Cushing syndrome), androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids (Conn syndrome)1
 
Mills SE, Carter D, Greenson JK, Oberman HA, Reuter VE
Sternberg's Diagnostic Surgical Pathology
4th Edition
Lippincott, Williams & Wilkins: Philadelphia 2004



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Histologically, the presence of severe cortical atrophy in adjacent non-neoplastic adrenal glands reflects significant suppression of the hypothalamic-pituitary-adrenal axis. These patients may need glucocorticoid supplementation
2
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Sasano H, Sato F, Shizawa S, Nagura H, Coughtrie MW (1995)
Immunolocalization of dehydroepiandrosterone sulfotransferase in normal and pathologic human adrenal gland.
Mod Pathol 8: 891-6



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The true incidence of adrenal cortical adenomas is unknown. Nodules are found commonly at autopsy and are more common with increasing age and with vascular diseases
3
 
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004



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