8310/3 Clear cell adenocarcinoma, NOS


Synonyms

Clear cell carcinoma


Definitions

Salivary glands
ICD-O-3 topography code: C07-C08
ICD10: C07-C08
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Nasal cavity and Sinuses
ICD-O-3 topography code: C30-C31
ICD10: C30-C31
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Lip, Oral Cavity and Oropharynx
ICD-O-3 topography code: C00-C06, C09-C10, C14
ICD10: C00-C06, C09-C10, C14
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Gallbladder and extrahepatic biliary tract
ICD-O-3 topography code: C23-C24.0
ICD10: C23-C24
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.

Clear cell adenocarcinoma of the gallbladder
This rare malignant neoplasm is composed predominantly of glycogen-rich clear cells with well-defined cytoplasmic borders and central hyperchromatic nuclei arranged in glandular or other growth patterns 1
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Albores-Saavedra J, Molberg K, Henson DE (1996)
Unusual malignant epithelial tumors of the gallbladder.
Semin Diagn Pathol 13: 326-38


 2
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Bittinger A, Altekrüger I, Barth P (1995)
Clear cell carcinoma of the gallbladder. A histological and immunohistochemical study.
Pathol Res Pract 191: 1259-65; discussion 1266


 3
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Suzuki M, Takahashi T, Ouchi K, Matsuno S (1989)
The development and extension of hepatohilar bile duct carcinoma. A three-dimensional tumor mapping in the intrahepatic biliary tree visualized with the aid of a graphics computer system.
Cancer 64: 658-66


 4
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Vardaman C, Albores-Saavedra J (1995)
Clear cell carcinomas of the gallbladder and extrahepatic bile ducts.
Am J Surg Pathol 19: 91-9


 . Some cells contain eosinophilic granular cytoplasm. Foci of conventional adenocarcinoma with mucin production are usually found and can distinguish primary carcinomas from metastatic clear cell carcinomas of the kidney. Exclusion of renal cell carcinoma is also accomplished by immunohistochemical labelling for PAX8 and RCC 5
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Avery AK, Beckstead J, Renshaw AA, Corless CL (2000)
Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms.
Am J Surg Pathol 24: 203-10


 . In some clear cell adenocarcinomas, the columnar cells contain subnuclear and supranuclear vacuoles similar to those seen in secretory endometrium. Production of α-fetoprotein has been documented in clear cell carcinomas with or without hepatoid differentiation 6
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Miyazawa M, Torii T, Toshimitsu Y, Kamizasa N, Suzuki T, Shinozuka N, Ishizawa K, Koyama I (2006)
Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts.
J Clin Gastroenterol 40: 555-7


 7
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Watanabe M, Asaka M, Tanaka J, Kurosawa M, Kasai M, Miyazaki T (1994)
Point mutation of K-ras gene codon 12 in biliary tract tumors.
Gastroenterology 107: 1147-53


 .



Prostate gland
ICD-O-3 topography code: C61
ICD10: C61
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Corpus uteri
ICD-O-3 topography code: C54
ICD10: C54
           

Clear cell adenocarcinoma of the uterine corpus is a malignant neoplasm arising from the endometrium. It is composed mainly of clear or hobnail glandular epithelial cells. Various architectural patterns may be seen, including tubular, papillary, tubulocystic, and solid. The tumour cells are rich in glycogen and project into lumina and papillary spaces. The nuclei are large and highly pleomorphic. Occasionally, the cytoplasm is granular rather than clear.
Clear cell adenocarcinoma of the uterine corpus belongs to the group of non-estrogen-dependent tumours. It affects predominantly older patients and is frequently diagnosed in advanced clinical stages. The prognosis is poor8
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003


 .



Penis
ICD-O-3 topography code: C60
ICD10: C60
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Thymus
ICD-O-3 topography code: C37
ICD10: C37
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Cervix uteri
ICD-O-3 topography code: C53
ICD10: C53
           

Clear cell adenocarcinoma is a malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.

Clear cell adenocarcinoma arises rarely in the cervix. Postmenopausal women are most often affected. In young women, there is an association with in utero exposure to diethylstilbestrol (DES) 9
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Boyd J, Takahashi H, Waggoner SE, Jones LA, Hajek RA, Wharton JT, Liu FS, Fujino T, Barrett JC, McLachlan JA (1996)
Molecular genetic analysis of clear cell adenocarcinomas of the vagina and cervix associated and unassociated with diethylstilbestrol exposure in utero.
Cancer 77: 507-13


 10
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003


 .



Region of the ampulla of Vater
ICD-O-3 topography code: C24.1
ICD10: C24.1
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.

Clear cell adenocarcinoma of the ampulla of Vater
This exceedingly rare form of ampullary carcinoma has a striking resemblance to metastatic renal cell carcinoma 11
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Albores-Saavedra J, Schwartz AM, Batich K, Henson DE (2009)
Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program.
J Surg Oncol 100: 598-605


 12
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Venu RP, Rolny P, Geenen JE, Hogan WJ, Komorowski RA, Ferstenberg R (1991)
Ampullary tumor caused by metastatic renal cell carcinoma.
Dig Dis Sci 36: 376-8


 . Clear cell carcinoma is composed predominantly or exclusively of polygonal cells with abundant clear cytoplasm, welldefined cytoplasmic membranes and centrally placed hyperchromatic nuclei. The cells are arranged in nests, cords or solid sheets and at least some contain cytoplasmic mucin, a useful feature that can distinguish it from renal cell carcinoma. Because of its rarity, the biological behaviour of clear cell carcinoma of the ampulla is unknown 13
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010


 .



Fallopian tube and Uterine ligaments
ICD-O-3 topography code: C57
ICD10: C57
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Vagina
ICD-O-3 topography code: C52
ICD10: C52
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Bronchus and lung
ICD-O-3 topography code: C34
ICD10: C34
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Urinary system: Renal pelvis, ureter, bladder, urethra
ICD-O-3 topography code: C65-C68
ICD10: C65-C68
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Ovary
ICD-O-3 topography code: C56
ICD10: C56
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.



Kidney
ICD-O-3 topography code: C64
ICD10: C64
           

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.