8247/3 Merkel cell tumor


Related terms

Merkel cell carcinoma

Definitions

Penis
ICD-O-3 topography code: C60
ICD10: C60
           

Merkel cell carcinoma (MCC) is a rare, highly malignant primary cutaneous neoplasm with neuroendocrine and epithelial differentiation 1
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



.
This tumour typically occurs on the sun-exposed skin of elderly patients, with a preference for males. Immunosuppression is a known risk factor. Recent evidence points to a causation by infection with Merkel cell polyomavirus (MCPyV)
2
Click to access Pubmed
Feng H, Shuda M, Chang Y, Moore PS (2008)
Clonal integration of a polyomavirus in human Merkel cell carcinoma.
Science 319: 1096-100



3
Click to access Pubmed
Kassem A, Schöpflin A, Diaz C, Weyers W, Stickeler E, Werner M, Zur Hausen A (2008)
Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene.
Cancer Res 68: 5009-13



.



Vulva
ICD-O-3 topography code: C51
ICD10: C51
           

Merkel cell carcinoma (MCC) is a rare, highly malignant primary cutaneous neoplasm with neuroendocrine and epithelial differentiation
4
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



.
This tumour typically occurs on the sun-exposed skin of elderly patients, with a preference for males. Immunosuppression is a known risk factor. Recent evidence points to a causation by infection with Merkel cell polyomavirus (MCPyV)
5
Click to access Pubmed
Feng H, Shuda M, Chang Y, Moore PS (2008)
Clonal integration of a polyomavirus in human Merkel cell carcinoma.
Science 319: 1096-100



6
Click to access Pubmed
Kassem A, Schöpflin A, Diaz C, Weyers W, Stickeler E, Werner M, Zur Hausen A (2008)
Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene.
Cancer Res 68: 5009-13



.

In the vulva, Merkel cell tumours are extremely rare and apparently behave more aggressively than at other sites
7
Click to access Pubmed
Gil-Moreno A, Garcia-Jiménez A, González-Bosquet J, Esteller M, Castellví­-Vives J, Martí­nez Palones JM, Xercavins J (1997)
Merkel cell carcinoma of the vulva.
Gynecol Oncol 64: 526-32



8
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



.



Skin
ICD-O-3 topography code: C44
ICD10: C44
           

Merkel cell carcinoma (MCC) is a rare, highly malignant primary cutaneous neoplasm with neuroendocrine and epithelial differentiation
9
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



.
This tumour typically occurs on the sun-exposed skin of elderly patients, with a preference for males. Immunosuppression is a known risk factor. Recent evidence points to a causation by infection with Merkel cell polyomavirus (MCPyV)
10
Click to access Pubmed
Feng H, Shuda M, Chang Y, Moore PS (2008)
Clonal integration of a polyomavirus in human Merkel cell carcinoma.
Science 319: 1096-100



11
Click to access Pubmed
Kassem A, Schöpflin A, Diaz C, Weyers W, Stickeler E, Werner M, Zur Hausen A (2008)
Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene.
Cancer Res 68: 5009-13



.