8211/3 Tubular adenocarcinoma


Tubular carcinoma


ICD-O-3 topography code: C16
ICD10: C16

Tubular adenocarcinoma is a histological variant characterized by a predominance of tube-like epithelial structures. Tubular adenocarcinoma of the stomach is composed of dilated or slit-like and branching tubules of varying diameter. Acinar structures may also be present 1
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010


ICD-O-3 topography code: C50
ICD10: C50

A special type of breast carcinoma with a particularly favourable prognosis, tubular carcinoma (TC) is composed of well-differentiated tubular structures with open lumina lined by a single layer of cells.

ICD-O-3 topography code: C44
ICD10: C44

Tubular carcinoma is the malignant counterpart of tubular adenoma, characterized by apocrine differentiation with prominent tubular and ductal structures. It arises in sites rich in apocrine glands, most frequently in the axilla. The tumour typically presents as a firm erythematous nodule, which may be ulcerated. It often involves the whole dermis and may extend into the subcutaneous tissue. Histologically, the tumour is asymmetric, poorly circumscribed and infiltrative and frequently contains areas of necrosis en masse. The stroma ist sparse. A frequent observation is decapitation secretion in the epithelial cells lining the tubules.
Tubular carcinoma arises most frequently in middle-aged patients and shows a slight predilection for women. The tumour is highly malignant and associated with a high rate of metastasis and death
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005