8170/0 Liver cell adenoma


Hepatocellular adenoma
Hepatoma, benign


Liver and intrahepatic bile ducts
ICD-O-3 topography code: C22

Hepatocellular adenoma (HCA) is a benign liver neoplasm composed of neoplastic hepatocytes. The incidence is about 3?4 per 100 000 population in Europe and North America 1
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Rooks JB, Ory HW, Ishak KG, Strauss LT, Greenspan JR, Hill AP, Tyler CW (1979)
Epidemiology of hepatocellular adenoma. The role of oral contraceptive use.
JAMA 242: 644-8

but lower in Asia. Eighty-five percent of cases occur in young women. The major risk factor for HCA is exposure to estrogenic or androgenic steroids; in young women with HCA, 80% have been users of oral contraceptives and risk increases with duration of use. Nonhormonal risk factors include glycogenosis type 1 (von Gierke disease) or 3 (Forbes disease), galactosaemia, tyrosinaemia, familial polyposis coli, and hepatic iron overload with β-thalassemia 2
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Shuangshoti S, Thaicharoen A (1994)
Hepatocellular adenoma in a beta-thalassemic woman having secondary iron overload.
J Med Assoc Thai 77: 108-12

. HCAs are classified into four different subtypes: (1) HNF1α-inactivated HCA, (2) β-Catenin-activated HCA, (3) inflammatory HCA and (4) unclassified HCA, which vary greatly in their clinical, pathological, and radiological features 3
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Bioulac-Sage P, Rebouissou S, Thomas C, Blanc JF, Saric J, Sa Cunha A, Rullier A, Cubel G, Couchy G, Imbeaud S, Balabaud C, Zucman-Rossi J (2007)
Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry.
Hepatology 46: 740-8

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Laumonier H, Bioulac-Sage P, Laurent C, Zucman-Rossi J, Balabaud C, Trillaud H (2008)
Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification.
Hepatology 48: 808-18

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Zucman-Rossi J, Jeannot E, Nhieu JT, Scoazec JY, Guettier C, Rebouissou S, Bacq Y, Leteurtre E, Paradis V, Michalak S, Wendum D, Chiche L, Fabre M, Mellottee L, Laurent C, Partensky C, Castaing D, Zafrani ES, Laurent-Puig P, Balabaud C, Bioulac-Sage P (2006)
Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC.
Hepatology 43: 515-24

. Evaluation of the size of HCA and recognition of the subtype by magnetic resonance imaging (MRI) and/or biopsy are important for patient management 6
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010