8160/0 Bile duct adenoma




Liver and intrahepatic bile ducts
ICD-O-3 topography code: C22

Bile duct adenoma (BDA) is usually single, usually < 1 cm in size, and is subcapsular and well-circumscribed but nonencapsulated. BDA is composed of a proliferation of small, uniform small-sized ducts with cuboidal cells that have regular nuclei. These ducts have no or little lumen and can elaborate mucin. Their associated fibrous stroma shows varying degrees of chronic inflammation and collagenization. Enclosed in the lesion are normally spaced portal tracts. BDA and peribiliary glands share common antigens, suggesting a common line of differentiation and leading some to consider it a peribiliary gland hamartoma 1
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Bhathal PS, Hughes NR, Goodman ZD (1996)
The so-called bile duct adenoma is a peribiliary gland hamartoma.
Am J Surg Pathol 20: 858-64

Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010