8151/3 Insulinoma, malignant


Beta cell tumor, malignant


ICD-O-3 topography code: C25
ICD10: C25

An insulinoma is a functionally active and commonly benign endocrine tumour of the pancreas with evidence of B-cell differentiation and clinical symptoms of hypoglycaemia due to inappropriate secretion of insulin 1
Ronald A. DeLellis, Ricardo V. Lloyd, Philipp U. Heitz, Charis Eng
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs
IARC Press: Lyon 2004


Insulinomas are the most frequent of all functioning pancreatic endocrine tumours
Kovacs K, Asa SL
Functional Endocrine Pathology
Blackwell Science Inc.: Oxford, Boston 1998

Damjanov I, Linder J
Andersonís Pathology
Mosby-Year Book Inc.: St. Louis 1996

. They have been diagnosed in all age groups, but rarely occur below the age of 15. The highest incidence is found between 40-60 years.
The etiology and pathogenesis of insulinomas are unknown. No risk factors have been associated with these tumours.
Malignant insulinomas may show gross local invasion of peripancreatic fatty tissue and/or adjacent organs such as the duodenum or the spleen. The first metastases are usually found in regional lymph nodes (peripancreatic, coeliac, periaortic) and the liver.