8144/3 Carcinoma, intestinal type



Definitions

Nasal cavity and Sinuses
ICD-O-3 topography code: C30-C31
ICD10: C30-C31
           

A variant of adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. It is histologically characterized by neoplastic tubular glands or papillary structures lined predominantly by cells with an intestinal phenotype, namely goblet cells or colonic-type epithelium or both, with or without a variable number of endocrine and Paneth cells 1
 
Hamilton SR, Aaltonen LA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
3rd Edition
IARC Press: Lyon 2000



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Gallbladder and extrahepatic biliary tract
ICD-O-3 topography code: C23-C24.0
ICD10: C23-C24
           

A variant of adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. It is histologically characterized by neoplastic tubular glands or papillary structures lined predominantly by cells with an intestinal phenotype, namely goblet cells or colonic-type epithelium or both, with or without a variable number of endocrine and Paneth cells
2
 
Hamilton SR, Aaltonen LA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
3rd Edition
IARC Press: Lyon 2000



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In the gallbladder, two morphological variants have been described
3
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



:
> Tubular cell variant
> Goblet cell variant



Region of the ampulla of Vater
ICD-O-3 topography code: C24.1
ICD10: C24.1
           

A variant of adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. It is histologically characterized by neoplastic tubular glands or papillary structures lined predominantly by cells with an intestinal phenotype, namely goblet cells or colonic-type epithelium or both, with or without a variable number of endocrine and Paneth cells
4
 
Hamilton SR, Aaltonen LA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
3rd Edition
IARC Press: Lyon 2000



.

Intestinal-type adenocarcinoma of the ampulla of Vater
This type of invasive adenocarcinoma is the most common malignant epithelial tumour of the ampulla and consists of simple or cribriformed tubular glands similar to those of adenocarcinomas of the colon. The glands are lined predominantly by columnar cells with pseudostratified oval or elongated nuclei showing varying degrees of atypia and a variable number of mitotic figures. In some carcinomas, goblet cells are interspersed with the columnar cells. Rarely, Paneth cells and endocrine cells are also present. Dirty-type necrosis as seen in adenocarcinomas of the colon is not as common in ampullary intestinal-type adenocarcinomas. Most of these tumours are associated with an adenoma. Adenocarcinomas arising in adenomas are usually smaller and have a better prognosis than adenocarcinomas unrelated to adenomas.



Cervix uteri
ICD-O-3 topography code: C53
ICD10: C53
           

A variant of adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. It is histologically characterized by neoplastic tubular glands or papillary structures lined predominantly by cells with an intestinal phenotype, namely goblet cells or colonic-type epithelium or both, with or without a variable number of endocrine and Paneth cells
5
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Stomach
ICD-O-3 topography code: C16
ICD10: C16
           

A variant of adenocarcinoma arising from epithelium which has undergone intestinal metaplasia. It is histologically characterized by neoplastic tubular glands or papillary structures lined predominantly by cells with an intestinal phenotype, namely goblet cells or colonic-type epithelium or both, with or without a variable number of endocrine and Paneth cells
6
 
Hamilton SR, Aaltonen LA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System.
3rd Edition
IARC Press: Lyon 2000



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