8081/2 Intraepidermal squamous cell carcinoma, Bowen type


Related terms

Bowen disease

Definitions

Skin
ICD-O-3 topography code: C44

/span>owen disease is a form of squamous cell carcinoma in situ. It is a distinct clinicopathological entity and arises from the skin or the mucocutaneous junction. The tumour most frequently develops on sun-exposed glabrous skin areas, particularly on head, face and neck, and presents as an erythematous, scaly, keratotic patch or plaque; multiple contiguos lesions can be observed frequently. Histologically, Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement membrane is intact. An inflammatory infiltrate of lymphocytes, macrophages, and plasma cells is typically found in the upper dermis.
Bowen disease affects predominantly white males (sex ratio 5:1) in their 6th-8th decades of life. UV damage and ingestion of inorganic arsenic may play a role in the development of the disease. Complete surgical removal of the lesion may be curative1
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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Penis
ICD-O-3 topography code: C60

Bowen disease is a form of squamous cell carcinoma in situ. It is a distinct clinicopathological entity and arises from the skin or the mucocutaneous junction. Histologically, Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement membrane is intact.
Bowen disease affects predominantly white males in their 6-8th decades of life. UV damage and ingestion of inorganic arsenic may play an etiological role. On the skin surface, it presents as a single or multiple erythematous, scaly, keratotic patches or plaques. Complete surgical removal is the treatment of choice and usually curative.

The clinical entity of queyrat erythroplasiais regarded as Bowen disease of the penis and it presents as an asymptomatic, red, circumscribed plaque.