8052/0 Keratotoc papilloma



Definitions

Anus and anal canal
ICD-O-3 topography code: C21

A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy. Most frequently it arises in the oral cavity, nasopharynx, larynx, esophagus, vagina, and vulva.

Squamous cell papilloma of the anal canal
Rarely, papillomatous processes covered by normal, more or less keratinized squamous epithelium can be found in the anus. Such lesions should be tested for the presence of human papillomavirus (HPV). Lesions that are negative for HPV are commonly regarded as ?burned-out? condylomas 1
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Urinary system: Renal pelvis, ureter, bladder, urethra
ICD-O-3 topography code: C65-C68

A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy. Most frequently it arises in the oral cavity, nasopharynx, larynx, esophagus, vagina, and vulva.



Bronchus and lung
ICD-O-3 topography code: C34

A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy. Most frequently it arises in the oral cavity, nasopharynx, larynx, esophagus, vagina, and vulva.



Cervix uteri
ICD-O-3 topography code: C53

Squamous cell papilloma is a benign epithelial neoplasm. Mature squamous epithelial cells without atypia or koilocytosis line a fibrovascular stalk, forming a single papillary frond. Most frequently, the tumour arises in the oral cavity, nasopharynx, larynx, esophagus, vagina, and vulva.
Squamous papillomas are rare in the cervix. They arise on the ectocervix or at the squamocolumnar junction and are usually solitary
2
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Vulva
ICD-O-3 topography code: C51

Squamous cell (vestibular) papilloma is a benign epithelial neoplasm characterized by a papillary architecture. A delicate fibrovascular stalk is bordered by a proliferation of neoplastic squamous cells without acanthosis or koilocytotic atypia. There is no morphologic evidence of malignancy. The lesions are <6mm in height and may be solitary or multiple. Multiple lesions often occur in clusters near the hymenal ring
3
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Vagina
ICD-O-3 topography code: C52

A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy. Most frequently it arises in the oral cavity, nasopharynx, larynx, esophagus, vagina, and vulva.



Esophagus
ICD-O-3 topography code: C15

A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy. Most frequently it arises in the oral cavity, nasopharynx, larynx, esophagus, vagina, and vulva.