9840/3 Acute myeloid leukemia, M6 type


Synonyms

Acute erythroid leukaemia
Erythroleukemia
FAB M6
AML M6
Erythremic myelosis, NOS
Acute erythremia
Di Guglielmo disease
Acute erythremic myelosis
M6B
M6A

Definitions

Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C94.0
           

/span>cute erythroid leukaemias are acute leukaemias that are characterized by a predominant erythroid population. Two subtypes are recognized based on the presence or absence of a significant myeloid (granulocytic) component:

Erythroleukaemia (erythroid/myeloid)
This subtype of acute erythroid leukaemia is defined by the presence in the BM of ≥50% erythroid precursors in the entire nucleated cell population and ≥20% myeloblasts in the non-erythroid cell population, i.e. the myeloblasts are calculated as a percent of the non-erythroid cells.

Pure erythroid leukaemia
This subtype of acute erythroid leukaemia represents a neoplastic proliferation of immature cells (undifferentiated or proerythroblastic in appearance) committed exclusively to the erythroid lineage (≥80% of BM cells) with no evidence of a significant myeloblastic component 1
Click to access Pubmed
Garand R, Duchayne E, Blanchard D, Robillard N, Kuhlein E, Fenneteau O, Salomon-Nguyen F, Grange MJ, Rousselot P, Demur C (1995)
Minimally differentiated erythroleukaemia (AML M6 'variant'): a rare subset of AML distinct from AML M6. Groupe Français d'Hématologie Cellulaire.
Br J Haematol 90: 868-75



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