9756/3 Langerhans cell sarcoma


Definitions

Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C96.4
           

/span>angerhans cell sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and the Langerhans cell phenotype.

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Thymus
ICD-O-3 topography code: C37
ICD10: C37
           

Langerhans cell sarcoma (LCS) is a rare neoplasm composed of cells with overtly malignant cytologic features and the Langerhans cell phenotype. Adult females are most commonly affected. LCS can present de novo or progress from antecedent Langerhans cell histiocytosis (LCH). Preferential sites of involvement are skin and underlying soft tissue, often with multi-organ invovlvement
3
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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Connective, subcutaneous and other soft tissues
ICD-O-3 topography code: C49
ICD10: C96.4
           

Langerhans cell sarcoma (LCS) is a rare neoplasm composed of cells with overtly malignant cytologic features and the Langerhans cell phenotype. Adult females are most commonly affected. LCS can present de novo or progress from antecedent Langerhans cell histiocytosis (LCH). Preferential sites of involvement are skin and underlying soft tissue, often with multi-organ invovlvement
4
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



.



Skin
ICD-O-3 topography code: C44
ICD10: C96.4
           

Langerhans cell sarcoma (LCS) is a rare neoplasm composed of cells with overtly malignant cytologic features and the Langerhans cell phenotype. Adult females are most commonly affected. LCS can present de novo or progress from antecedent Langerhans cell histiocytosis (LCH). Preferential sites of involvement are skin and underlying soft tissue, often with multi-organ invovlvement
5
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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