9732/3 Multiple myeloma


Synonyms

Myelomatosis
Plasma cell myeloma
Myeloma, NOS

Definitions

Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C90.0
           

/span>lasma cell myeloma is a BM-based, multi?focal plasma cell neoplasm associated with an M-protein in serum and/or urine. In most cases there is disseminated BM involvement. The disease spans a clinical spectrum from asymptomatic to aggressive forms and disorders due to deposition of abnormal immunoglobulin chains in tissues 1
 
Malpas J, Bergsagel D, Kyle R, Anderson K (Eds.)
Myeloma: Biology and Management
3rd Edition
Saumders: Philadelphia 2004



. The diagnosis is based on a combination of pathological, radiological and clinical features (Table 10.05).

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Bone
ICD-O-3 topography code: C40-C41
ICD10: C90.0
           

Plasma cell myeloma is a bone marrow (BM)-based, multifocal plasma cell neoplasm associated with an M-protein in serum and/or urine
4
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



. The disease ranges clinically from asymptomatic to aggressive forms due to deposition of abnormal immunoglobulin chains in tissues, including non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. Clinical signs and symptoms include skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia 5
 
Malpas J, Bergsagel D, Kyle R, Anderson K (Eds.)
Myeloma: Biology and Management
3rd Edition
Saumders: Philadelphia 2004



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