9731/3 Plasmacytoma, NOS


Synonyms

Plasma cell tumor
Solitary myeloma
Solitary plasmacytoma
Plasmacytoma of bone

Definitions

Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C90.3
           

/span>olitary plasmacytoma of bone (osseous plasmacytoma) is a localized bone tumour consisting of monoclonal plasma cells. Complete skeletal radiographs show no other lesions. There are no clinical features of plasma cell myeloma and no evidence of BM plasmacytosis except for the solitary lesion 1
Click to access Pubmed
(2003)
Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group.
Br J Haematol 121: 749-57



2
Click to access Pubmed
Soutar R, Lucraft H, Jackson G, Reece A, Bird J, Low E, Samson D, , , (2004)
Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma.
Br J Haematol 124: 717-26



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Bone
ICD-O-3 topography code: C40-C41
ICD10: C90.3
           

Solitary plasmacytoma of bone (osseous plasmacytoma) is a localized bone tumour consisting of monoclonal plasma cells. it comprises 3-5% of plasma cell tumours and there are no clinical features of plasma cell myeloma and no evidence of BM plasmacytosis
6
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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It is more common in men and the median age at diagnosis is 55 years. The most common sites are bones with active BM haematopoiesis, in order of frequency the vertebrae, ribs, skull, pelvis, femur, clavicle and scapula. Patients typically present with bone pain at the site of the lesion or with a pathological fracture. Vertebral lesions may be associated with symptomatic cord compression
7
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



8
 
Malpas J, Bergsagel D, Kyle R, Anderson K (Eds.)
Myeloma: Biology and Management
3rd Edition
Saumders: Philadelphia 2004



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