9673/3 Mantle zone lymphoma


Related terms

Mantle cell lymphoma

Definitions

Small intestine
ICD-O-3 topography code: C17
ICD10: C83.1
           

Mantle cell lymphoma (MCL) is an aggressive, usually diffuse non-Hodgkin lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes). The t(11;14)(q13;q32) translocation causes an overexpression of cyclin D1 (CCND1), is present in almost all cases and considered the primary genetic event 1
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



. MCL manisfests preferentially in middle-aged to older male patients with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site, occasionally as lymphomatous polyposis.



Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C83.1
           

/span>antle cell lymphoma (MCL) is a B-cell neoplasm generally composed of mono?morphic small to medium-sized lymphoid cells with irregular nuclear contours and a CCND1 translocation
2
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Banks PM, Chan J, Cleary ML, Delsol G, De Wolf-Peeters C, Gatter K, Grogan TM, Harris NL, Isaacson PG, Jaffe ES (1992)
Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular data.
Am J Surg Pathol 16: 637-40



3
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Campo E, Raffeld M, Jaffe ES (1999)
Mantle-cell lymphoma.
Semin Hematol 36: 115-27



4
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Lardelli P, Bookman MA, Sundeen J, Longo DL, Jaffe ES (1990)
Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunophenotypic spectrum and clinical correlations.
Am J Surg Pathol 14: 752-63



5
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Lennert K, Stein H, Kaiserling E (1975)
Cytological and functional criteria for the classification of malignant lymphomata.
Br J Cancer Suppl 2: 29-43



6
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Parry-Jones N, Matutes E, Morilla R, Brito-Babapulle V, Wotherspoon A, Swansbury GJ, Catovsky D (2007)
Cytogenetic abnormalities additional to t(11;14) correlate with clinical features in leukaemic presentation of mantle cell lymphoma, and may influence prognosis: a study of 60 cases by FISH.
Br J Haematol 137: 117-24



7
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Swerdlow SH, Habeshaw JA, Murray LJ, Dhaliwal HS, Lister TA, Stansfeld AG (1983)
Centrocytic lymphoma: a distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse.
Am J Pathol 113: 181-97



8
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Tolksdorf G, Stein H, Lennert K (1980)
Morphological and immunological definition of a malignant lymphoma derived from germinal-centre cells with cleaved nuclei (centrocytes).
Br J Cancer 41: 168-82



. Neoplastic trans?formed cells (centroblasts), paraimmuno?blasts and proliferation centres are absent.

>



Lip, Oral Cavity and Oropharynx
ICD-O-3 topography code: C00-C06, C09-C10, C14
ICD10: C83.1
           

Mantle cell lymphoma (MCL) is an aggressive, usually diffuse non-Hodgkin lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes). The t(11;14)(q13;q32) translocation causes an overexpression of cyclin D1 (CCND1), is present in almost all cases and considered the primary genetic event
10
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



.
MCL manisfests preferentially in middle-aged to older male patients with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site, occasionally as
lymphomatous polyposis.



Colon and rectum
ICD-O-3 topography code: C18-C20
ICD10: C83.1
           

Mantle cell lymphoma (MCL) is an aggressive, usually diffuse non-Hodgkin lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes). The t(11;14)(q13;q32) translocation causes an overexpression of cyclin D1 (CCND1), is present in almost all cases and considered the primary genetic event
11
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



. MCL manisfests preferentially in middle-aged to older male patients with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site, occasionally as lymphomatous polyposis.



Stomach
ICD-O-3 topography code: C16
ICD10: C83.1
           

Mantle cell lymphoma (MCL) is an aggressive, usually diffuse non-Hodgkin lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes). The t(11;14)(q13;q32) translocation causes an overexpression of cyclin D1 (CCND1), is present in almost all cases and considered the primary genetic event
12
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



.
MCL manifests preferentially in middle-aged to older male patients with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site, occasionally as lymphomatous polyposis.



Skin
ICD-O-3 topography code: C44
ICD10: C83.1
           

Mantle cell lymphoma (MCL) is an aggressive, usually diffuse non-Hodgkin lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes). The t(11;14)(q13;q32) translocation causes an overexpression of cyclin D1 (CCND1), is present in almost all cases and considered the primary genetic event
13
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



.
MCL manisfests preferentially in middle-aged to older male patients with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site, occasionally as
lymphomatous polyposis.