9670/3 Malignant lymphoma, small cell diffuse



Definitions

Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C83.0
           

Small lymphocytic lymphoma (SLL) is composed of monomorphic small, round B-lymphocytes in the lymph nodes, with the phenotype of chronic lymphocytic leukemia (CLL), CD5+, CD23+.1
 
Jaffe ES, Harris NL, Stein H, Vardiman JW (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues.
3rd Edition
IARC Press: Lyon 2001



. The term SLL is used only in the absence of peripheral blood or bone marrow involvement. These terms are most often combined as chronic lymphocytic leukaemia / small lymphocytic lymphoma2
 
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



, as this is considered a single disease, whether the predominant involvement is in bone marrow or lymph nodes, or other sites.