9659/3 Hodgkin lymphoma, nodular lymphocyte predominance


Synonyms

Hodgkin lymphoma, lymphocyte predominance, nodular
Hodgkin paragranuloma, NOS
Hodgkin paragranuloma, nodular

Definitions

Tumours of haematopoietic and lymphoid tissues
ICD-O-3 topography code: C42 and C77
ICD10: C81.0
           

/span>odular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells) ?formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. These cells reside in large spherical meshworks of follicular dendritic cell processes that are filled with non-neoplastic lymphocytes and histiocytes.

One third of the cases ?diagnosed in the past as NLPHL were lymphocyte-rich classical HL. It is currently not clear whether a purely diffuse form of NLPHL exists. Most lesions diagnosed in the past as diffuse LPHL were probably T-cell/histiocyte rich large B-cell lymphoma(TCRBCL). At present an overlap between NLPHL and TCRBCL cannot be excluded.

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