9450/3 Oligodendroglioma, NOS


Definitions

Tumours of the central nervous system
ICD-O-3 topography code: C70, C71 and C72
ICD10: C71
           

A well-differentiated (WHO grade II), diffusely infiltrating glioma of adults, typically located in the cerebral hemispheres and composed predominantly of cells that morphologically resemble oligodendroglia. Typically, neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance)1
 
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (Eds.)
WHO Classification of Tumours of the Central Nervous System.
4th Edition
International Agency for Research on Cancer: Lyon 2007



. Deletion of 1p and 19q and IDH1/2 mutations are genetic hallmarks. On a population-based level, 5 and 10 years survival rates of 78-79% and 51-64%, respectively have been reported 2
Click to access Pubmed
Okamoto Y, Di Patre PL, Burkhard C, Horstmann S, Jourde B, Fahey M, Schüler D, Probst-Hensch NM, Yasargil MG, Yonekawa Y, Lütolf UM, Kleihues P, Ohgaki H (2004)
Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas.
Acta Neuropathol 108: 49-56



http://www.cbtrus.org/reports/reports.html .