9442/3 Gliosarcoma


Synonyms

Glioblastoma with sarcomatous component

Definitions

Tumours of the central nervous system
ICD-O-3 topography code: C70, C71 and C72
ICD10: C71
           

A glioblastoma variant characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation 1
 
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (Eds.)
WHO Classification of Tumours of the Central Nervous System.
4th Edition
International Agency for Research on Cancer: Lyon 2007



. Genetic analyses have shown that this is a monoclonal tumour with focal aberrant mesenchymal differentiation caused by advanced genomic instability.
Clinical signs and symptoms, treatment and prognosis are similar to those of a primary glioblastoma.