9440/3 Glioblastoma


Synonyms

Glioblastoma multiforme
Spongioblastoma multiforme

Definitions

Tumours of the central nervous system
ICD-O-3 topography code: C70, C71 and C72
ICD10: C71
           

Glioblastoma multiforme (GBM) is the most common and most malignant brain tumour. It is composed of poorly differentiated neoplastic astrocytes, typically affects adults and is preferentially located in the cerebral hemispheres 1
 
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (Eds.)
WHO Classification of Tumours of the Central Nervous System.
4th Edition
International Agency for Research on Cancer: Lyon 2007



. Despite recent therapeutic progress 2
Click to access Pubmed
DeAngelis LM (2005)
Chemotherapy for brain tumors--a new beginning.
N Engl J Med 352: 1036-8



3
Click to access Pubmed
Stupp R, Roila F, (2008)
Malignant glioma: ESMO clinical recommendations for diagnosis, treatment and follow-up.
Ann Oncol 19 Suppl 2: ii83-5



, the prognosis is still poor.
Glioblastomas may develop from low-grade or anaplastic astrocytomas (secondary glioblastoma), but more frequently, they manifest after a short clinical history de novo, with no evidence of a less malignant precursor lesion (primary glioblastoma)
4
Click to access Pubmed
Ohgaki H, Kleihues P (2013)
The definition of primary and secondary glioblastoma.
Clin Cancer Res 19: 764-72



. Histopathologically, these subtypes cannot reliably be distinguished 5
 
McLendon RE, Rosenblum MK, Bigner DD (Eds.)
Russell and Rubinstein's Pathology of Tumours of the Nervous System
7th Edition
Hodder Arnold: London 2006



6
 
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (Eds.)
WHO Classification of Tumours of the Central Nervous System.
4th Edition
International Agency for Research on Cancer: Lyon 2007



7
 
Burger PC, Scheithauer B
Tumors of the Central Nervous System
AFIP Atlas of Tumour Pathology, Series 4, Fascicle 7
American Registry of Pathology: Washington DC 2008



.

Histological variants of glioblastoma:
Giant cell glioblastoma
Gliosarcoma