9430/3 Astroblastoma


Definitions

Tumours of the central nervous system
ICD-O-3 topography code: C70, C71 and C72
ICD10: C71
           

A rare glial neoplasm typically manifesting in the cerbral hemispheres of children and young adults. It is usually well-circumsrcribed and histologically characterized by GFAP-expressing tumor cells in a perivascular ararrangement, forming astroblastic pseudorosettes. The cells have broad, non-tapering processes radiating towards a central blood vessel that often shows hyalin-type sclerosis 1
 
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (Eds.)
WHO Classification of Tumours of the Central Nervous System.
4th Edition
International Agency for Research on Cancer: Lyon 2007



2
Click to access Pubmed
Brat DJ, Hirose Y, Cohen KJ, Feuerstein BG, Burger PC (2000)
Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization.
Brain Pathol 10: 342-52



3
Click to access Pubmed
Bonnin JM, Rubinstein LJ (1989)
Astroblastomas: a pathological study of 23 tumors, with a postoperative follow-up in 13 patients.
Neurosurgery 25: 6-13



. The clinical behaviour of astroblastoma is variable and depends on the grade of the tumor and extent of resection 4
Click to access Pubmed
Brat DJ, Hirose Y, Cohen KJ, Feuerstein BG, Burger PC (2000)
Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization.
Brain Pathol 10: 342-52



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