9104/1 Placental site trophoblastic tumor


Definitions

Corpus uteri
ICD-O-3 topography code: C54

Placental site trophoblastic tumour is a rare gestational neoplasm characterized by a diffuse cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts. There is no significant population of syncytiotrophoblasts. The neoplastic cells are medium-sized to large, mononuclear or multinucleated. They are characterized by mild to marked nuclear atypia, prominent nucleoli, eosinophilic to clear cytoplasm, scattered mitoses and occasional intranuclear inclusions. The tumour infiltrates the myometrium and vessels in a manner similar to the implantation site trophoblast.
Major adverse prognostic variable for placental site trophoblastic tumours is a long (>4 years) interval from the last antecedent pregnancy1
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



.



Testis/Male genital organs
ICD-O-3 topography code: C62-C63

A rare gestational trophoblastic tumor characterized by the presence of a diffuse cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts and by the absense of a significant population of syncytiotrophoblasts.



Fallopian tube and Uterine ligaments
ICD-O-3 topography code: C57

A rare gestational trophoblastic tumor characterized by the presence of a diffuse cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts and by the absense of a significant population of syncytiotrophoblasts.