9013/0 Adenofibroma, NOS



Definitions

Cervix uteri
ICD-O-3 topography code: C53

Adenofibroma is a benign neoplasm characterized by the presence of connective tissue stroma and epithelial structures.
Cervical adenofibromas are rare. They present as polypoid masses that usually protrude into the endocervical canal. The tumour is composed of fronds lined by benign, generally glandular, epithelium. The mesenchymal component typically consists of non-specific fibrous tissue.
Complete local excision is usually curative1
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Kidney
ICD-O-3 topography code: C64

A benign neoplasm histologically characterized by the presence of connective tissue stroma and epithelial structures
2
 
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Metanephric adenofibromas of the kidney are typically solitary, partially cystic masses. They are composed of nodules of epithelium identical to metanephric adenoma that are embedded in sheets of moderately cellular spindle cells. The borders of the tumour are typically ill-defined and irregular
3
 
Eble JE, Sauter G, Epstein JI, Sesterhenn IA (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs.
3rd Edition
IARC Press: Lyon 2004



. There is no tendency for malignant progression and the prognosis is favourable.



Corpus uteri
ICD-O-3 topography code: C54

Adenofibroma is a benign neoplasm characterized by the presence of connective tissue stroma and epithelial structures.
Uterine adenofibromas typically present as polypoid lesions with a papillary or clublike growth pattern. Dilated cystic spaces are frequently observed. Occasionally, the tumour may superficially invade the myometrium.
Uterine adenofibroma is an uncommon neoplasm. It affects most often postmenopausal patients but it may also arise in younger women. The tumour is benign, although it may recur after "polypectomy"
4
Click to access Pubmed
Seltzer VL, Levine A, Spiegel G, Rosenfeld D, Coffey EL (1990)
Adenofibroma of the uterus: multiple recurrences following wide local excision.
Gynecol Oncol 37: 427-31



. Metastases have not been reported5
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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