8083/3 Basaloid squamous cell carcinoma


Definitions

Vagina
ICD-O-3 topography code: C52
ICD10: C52
           

A squamous cell carcinoma histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading.



Cervix uteri
ICD-O-3 topography code: C53
ICD10: C53
           

Basaloid squamous cell carcinoma is an aggressive histological variant of squamous cell carcinoma characterized by basaloid features. It is composed of nests of immature, basal-type squamous cells with scanty cytoplasm, hyperchromatic nuclei, and peripheral nuclear palisading. There may be some keratinization in the centres of the nests, but keratin pearls are rare1
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Esophagus
ICD-O-3 topography code: C15
ICD10: C15
           

A squamous cell carcinoma (SCC) histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading.

Basaloid squamous cell carcinoma of the esophagus has a similar appearance to adenoid cystic carcinoma but is more aggressive
2
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Li TJ, Zhang YX, Wen J, Cowan DF, Hart J, Xiao SY (2004)
Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features.
Arch Pathol Lab Med 128: 1124-30



. The presence of associated squamous carcinoma in situ is a strong argument for the diagnosis of basaloid carcinoma. Basaloid SCC is a distinct, unusual variant that occurs more commonly in the upper aerodigestive tract 3
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Banks ER, Frierson HF, Mills SE, George E, Zarbo RJ, Swanson PE (1992)
Basaloid squamous cell carcinoma of the head and neck. A clinicopathologic and immunohistochemical study of 40 cases.
Am J Surg Pathol 16: 939-46



4
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Tsang WY, Chan JK, Lee KC, Leung AK, Fu YT (1991)
Basaloid-squamous carcinoma of the upper aerodigestive tract and so-called adenoid cystic carcinoma of the oesophagus: the same tumour type?
Histopathology 19: 35-46



. It is more common in older men, who present with dysphagia. Microscopically, it consists of basaloid cells with oval to round nuclei, open pale chromatin, and scant basophilic cytoplasm. It is arranged in solid or cribriform lobules with comedonecrosis 5
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Kobayashi Y, Nakanishi Y, Taniguchi H, Sekine S, Igaki H, Tachimori Y, Kato H, Matsubara H, Okazumi S, Shimoda T (2009)
Histological diversity in basaloid squamous cell carcinoma of the esophagus.
Dis Esophagus 22: 231-8



. Areas of squamous intraepithelial neoplasia or conventional SCC are commonly observed 6
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Wain SL, Kier R, Vollmer RT, Bossen EH (1986)
Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases.
Hum Pathol 17: 1158-66



. Adenoid cystic carcinoma and basaloid squamous cell carcinoma should be distinguished: adenoid cystic carcinoma is less aggressive 7
Click to access Pubmed
Wain SL, Kier R, Vollmer RT, Bossen EH (1986)
Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases.
Hum Pathol 17: 1158-66



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Lip, Oral Cavity and Oropharynx
ICD-O-3 topography code: C00-C06, C09-C10, C14
ICD10: C00-C06, C09-C10, C14
           

A squamous cell carcinoma histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading.



Penis
ICD-O-3 topography code: C60
ICD10: C60
           

A squamous cell carcinoma histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading.



Hypopharynx, Larynx and Trachea
ICD-O-3 topography code: C13, C32, C33
ICD10: C13, C32, C33
           

A squamous cell carcinoma histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading.



Nasal cavity and Sinuses
ICD-O-3 topography code: C30-C31
ICD10: C30-C31
           

A squamous cell carcinoma histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading.



Bronchus and lung
ICD-O-3 topography code: C34
ICD10: C34
           

A squamous cell carcinoma histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading.



Vulva
ICD-O-3 topography code: C51
ICD10: C51
           

Basaloid squamous cell carcinoma is a variant of squamous cell carcinoma histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading
8
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



.



Nasopharynx
ICD-O-3 topography code: C11
ICD10: C11.9
           

A squamous cell carcinoma histologically characterized by the presence of cells with hyperchromatic nuclei, scant amount of cytoplasm, and peripheral nuclear palisading.