8980/3 Carcinosarcoma, NOS


Definitions

Liver and intrahepatic bile ducts
ICD-O-3 topography code: C22
ICD10: C22
           

A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. Genetic analyses indicate that these are monoclonal tumours with digergent lines of differentiation. These neoplasms are currently understood to be carcinomas that have undergone sarcoma-like differentiation (sarcomatoid carcinoma). The sarcomatoid component represents clonal evolution from the differentiated component (hepatocellular or cholangiocarcinoma). Morphology varies from spindled to epithelioid and pleomorphic. Mitotic rate is usually high, and atypical mitoses are frequent. These are clinically aggressive tumours with a poor prognosis 1
 
Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Corpus uteri
ICD-O-3 topography code: C54
ICD10: C54
           

Carcinosarcoma is a malignant tumour composed of a mixture of carcinomatous and sarcomatous elements. Genetic analyses indicate that these are monoclonal tumours with divergent lines of differentiation.
Uterine carcinosarcomas typically present as polypoid, bulky, necrotic and haemorrhagic neoplasms that fill the endometrial cavity and invade deeply into the myometrium, often extending beyond the uterus. The uterus is enlarged. The epithelial and mesenchymal components are sharply demarcated in most cases. The epithelial element is typically glandular. Eosinophilic hyaline inclusions are frequent, especially in the mesenchymal components.
Carcinosarcomas predominantly arise in elderly postmenopausal women (median age 65 years). The most common symptom is vaginal bleeding. The clinical course is usually aggressive, the overall prognosis is poor. Recurrences are common. Carcinosarcomas primarily spread via lymphatics. They frequently develop intra-abdominal and retroperitoneal nodal metastases. The prognosis for tumours confined to an otherwise benign polyp appears to be sligthly better
2
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Bronchus and lung
ICD-O-3 topography code: C34
ICD10: C34
           

A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. Genetic analyses indicate that these are monoclonal tumours with digergent lines of differentiation.



Cervix uteri
ICD-O-3 topography code: C53
ICD10: C53
           

Carcinosarcoma is a malignant tumour composed of a mixture of carcinomatous and sarcomatous elements. Genetic analyses indicate that these are monoclonal tumours with divergent lines of differentiation.

Cervical carcinosarcomas may occur in all age groups, but most commonly arise in postmenopausal women. Patients typically present with abnormal uterine bleeding. The tumours are aggressive, the usual treatment is radical hysterctomy followed by chemotherapy and/or radiotherapy. Small tumours with a polypoid appearance may have a better prognosis
3
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Vagina
ICD-O-3 topography code: C52
ICD10: C52
           

A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. Genetic analyses indicate that these are monoclonal tumours with digergent lines of differentiation.



Salivary glands
ICD-O-3 topography code: C07-C08
ICD10: C07-C08
           

A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. Genetic analyses indicate that these are monoclonal tumours with digergent lines of differentiation.



Thymus
ICD-O-3 topography code: C37
ICD10: C37
           

A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. Genetic analyses indicate that these are monoclonal tumours with digergent lines of differentiation.



Ovary
ICD-O-3 topography code: C56
ICD10: C56
           

A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements. Genetic analyses indicate that these are monoclonal tumours with digergent lines of differentiation.