8940/0 Pleomorphic adenoma


Synonyms

Mixed tumor, NOS
Mixed tumor, salivary gland type, NOS

Related terms

Chondroid syringoma

Definitions

Salivary glands
ICD-O-3 topography code: C07-C08

A neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It usually presents as a slowly growing painless mass. It may recur after excision or transform to a malignant carcinoma ex pleomorphic adenoma.



Breast
ICD-O-3 topography code: C50

A tumour of the breast that is morphologically similar to pleomorphic adenoma (PA) of the salivary glands.





Skin
ICD-O-3 topography code: C44

Cutaneous mixed tumours (pleomorphic adenomas) are benign adnexal neoplasms. They typically present as solitary, slow-growing dermal/subcutaneous nodules, most frequently on the head and neck. The lesions are well-circumscribed and range in diameter from 1 to 3 cm (in some cases up to 6cm). The growth pattern is biphasic; epithelial cells, often arranged in tubules, solid cords, or islands are surrounded by myoepithelial cells and mesenchymal components. The stroma may be myxoid, chondroid, fibrous, or osteoid, and typically constitutes at least half of the tumour.
Cutaneous mixed tumours affect adults and show a predilection for males. Contrary to the histologically identical mixed tumours of the salivary gland, cutaneous mixed tumours have no tendency for local recurrence; simple excision is curative4
 
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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Lip, Oral Cavity and Oropharynx
ICD-O-3 topography code: C00-C06, C09-C10, C14

A neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It usually presents as a slowly growing painless mass. It may recur after excision or transform to a malignant carcinoma ex pleomorphic adenoma.



Hypopharynx, Larynx and Trachea
ICD-O-3 topography code: C13, C32, C33

A neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It usually presents as a slowly growing painless mass. It may recur after excision or transform to a malignant carcinoma ex pleomorphic adenoma.



Nasal cavity and Sinuses
ICD-O-3 topography code: C30-C31

A neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It usually presents as a slowly growing painless mass. It may recur after excision or transform to a malignant carcinoma ex pleomorphic adenoma.



Vagina
ICD-O-3 topography code: C52

A neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It usually presents as a slowly growing painless mass. It may recur after excision or transform to a malignant carcinoma ex pleomorphic adenoma.



Bronchus and lung
ICD-O-3 topography code: C34

A neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It usually presents as a slowly growing painless mass. It may recur after excision or transform to a malignant carcinoma ex pleomorphic adenoma.



Vulva
ICD-O-3 topography code: C51

A neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It usually presents as a slowly growing painless mass. It may recur after excision or transform to a malignant carcinoma ex pleomorphic adenoma.

Pleomorphic adenoma of the vulva is a rare tumour with few reported cases. It usually arises in the labum majus and/or Bartholin gland area and presents as a subcutaneous nodule. The tumour may recur locally. Recommended treatment is complete local excision with free margins
5
Click to access Pubmed
Rorat E, Wallach RC (1984)
Mixed tumors of the vulva: clinical outcome and pathology.
Int J Gynecol Pathol 3: 323-8



6
Click to access Pubmed
Dykgraaf RH, van Veen MM, van Bekkum-de Jonge EE, Gerretsen J, de Jong D, Burger CW (2006)
Pleomorphic adenoma of the vulva: a review illustrated by a clinical case.
Int J Gynecol Cancer 16: 920-3



7
 
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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Connective, subcutaneous and other soft tissues
ICD-O-3 topography code: C49

A neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It usually presents as a slowly growing painless mass. It may recur after excision or transform to a malignant carcinoma ex pleomorphic adenoma.