8930/3 Endometrial stromal sarcoma, high grade


Corpus uteri
ICD-O-3 topography code: C54
ICD10: C54

Undifferentiated endometrial sarcoma is an aggressive high-grade mesenchymal tumour arising from the uterine corpus. It lacks specific differentiation and any resemblance to the endometrial stroma. The tumour appears as a polypoid, fleshy, grey to yellow mass in the endometrium. Areas of prominent haemorrhage and necrosis are frequent observations. Histologically, the tumour exhibits marked cellular atypia and high mitotic activity. In contrast to the infiltrative growth pattern of low grade endometrial sarcoma, undifferentiated endometrial sarcomas displace the myometrium.
Most patients die from tumour dissemination within three years after hysterectomy 1
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003